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Outcomes after hematopoietic stem cell transplantation HSCT for patients with both malignant and nonmalignant diseases have improved significantly in recent years. Ovarian failure and subsequent infertility are frequent complications that long-term HSCT survivors and their partners face with a negative impact on their QoL. Several meta-analyses of randomized clinical trials showed that gonadotropin-releasing hormone agonist GnRHa administration in advance of starting standard chemotherapy decreases the risk of gonadal dysfunction and infertility in cancer patients, but GnRHa use for ovarian protection in HSCT patients is not fully determined. Hematopoietic stem cell transplantation HSCT is increasingly used for the treatment of both malignant and nonmalignant diseases. Instead, long-term side effects are important to recognize and treat 1 , 2 , 3 to maintain a good quality of life QoL for HSCT recipients 4 , 5.
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Manchester United boss Ole Gunnar Solskjaer will address the media today ahead of the Europa League fixture against FK Partizan - after the team held an open training session. Ethan Laird is another who could feature. Martial could return to the starting line up on Thursday night and so could the returning Jesse Lingard. Follow all the latest Manchester United news and updates on our live blog below. Various outlets are reporting that Manchester United have reached an agreement to sign Real Zaragoza youngster - Mateo Mejia.
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